MovDisordV3, Main, Exploration, bibRecord, 001187

Brain Organochlorines and Lewy Pathology: The Honolulu-Asia Aging Study

Identifieur interne : 001187 ( Main/Exploration ); précédent : 001186; suivant : 001188

Brain Organochlorines and Lewy Pathology: The Honolulu-Asia Aging Study

Auteurs : G. Webster Ross [États-Unis] ; John E. Duda [États-Unis] ; Robert D. Abbott [États-Unis] ; Edo Pellizzari [États-Unis] ; Helen Petrovitch [États-Unis] ; Diane B. Miller [États-Unis] ; James P. O'Callaghan [États-Unis] ; Caroline M. Tanner [États-Unis] ; Joseph V. Noorigian [États-Unis] ; Kamal Masaki [États-Unis] ; Lenore Launer [États-Unis] ; Lon R. White [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0393078

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Encéphale, Anatomopathologie, Sénescence, Corps Lewy, Pesticide.
Wicri :
- topic : Pesticide.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Aging (pathology), Anatomic pathology, Asian Americans, Brain (metabolism), Brain (pathology), Cohort Studies, Encephalon, Hawaii, Humans, Hydrocarbons, Chlorinated (metabolism), Lewy Bodies (pathology), Lewy body, Male, Nervous system diseases, Parkinson disease, Pesticides, Senescence.
MESH :
- chemical , metabolism : Hydrocarbons, Chlorinated.
- geographic : Hawaii.
- metabolism : Brain.
- pathology : Aging, Brain, Lewy Bodies.
- Aged, Aged, 80 and over, Asian Americans, Cohort Studies, Humans, Male.

Abstract

Although organochlorines have been reported more frequently in Parkinson's disease (PD) brains than in controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during midlife, represent a population well suited to determining the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS. The study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites. With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found in at least 1 brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. The prevalence of Lewy pathology was 75% (6 of 8) among brains with any 2 of the 3 compounds, 48.8% (79 of 162) among those with 1, and 32.7% (18 of 55) for those with neither (P = .007 test for trend). Although findings persisted after removing cases with PD and dementia with Lewy bodies and after adjustment for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (P = .013), the results were insignificant when correcting for multiple testing. Although consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474594

Affiliations:

Le document en format XML

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<author><name sortKey="Miller, Diane B" sort="Miller, Diane B" uniqKey="Miller D" first="Diane B." last="Miller">Diane B. Miller</name>
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<author><name sortKey="O Callaghan, James P" sort="O Callaghan, James P" uniqKey="O Callaghan J" first="James P." last="O'Callaghan">James P. O'Callaghan</name>
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<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
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<s2>Sunnyvale, California</s2>
<s3>USA</s3>
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<author><name sortKey="Noorigian, Joseph V" sort="Noorigian, Joseph V" uniqKey="Noorigian J" first="Joseph V." last="Noorigian">Joseph V. Noorigian</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Philadelphia Veterans Affairs Medical Center</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Kuakni Medical Center/Honolulu-Asia Aging Study</s1>
<s2>Honolulu, Hawaii</s2>
<s3>USA</s3>
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<placeName><region type="state">Hawaï</region>
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<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Medicine, John A. Burns School of Medicine, University of Hawai</s1>
<s2>Honolulu, Hawaii</s2>
<s3>USA</s3>
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<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Geriatrics, John A. Burns School of Medicine, University of Hawai</s1>
<s2>Honolulu, Hawaii</s2>
<s3>USA</s3>
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<author><name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>National Institute on Aging, National Institutes of Health</s1>
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<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Kuakni Medical Center/Honolulu-Asia Aging Study</s1>
<s2>Honolulu, Hawaii</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Medicine, John A. Burns School of Medicine, University of Hawai</s1>
<s2>Honolulu, Hawaii</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Geriatrics, John A. Burns School of Medicine, University of Hawai</s1>
<s2>Honolulu, Hawaii</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Hawaï</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging (pathology)</term>
<term>Anatomic pathology</term>
<term>Asian Americans</term>
<term>Brain (metabolism)</term>
<term>Brain (pathology)</term>
<term>Cohort Studies</term>
<term>Encephalon</term>
<term>Hawaii</term>
<term>Humans</term>
<term>Hydrocarbons, Chlorinated (metabolism)</term>
<term>Lewy Bodies (pathology)</term>
<term>Lewy body</term>
<term>Male</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Pesticides</term>
<term>Senescence</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocarbons, Chlorinated</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Hawaii</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term>
<term>Brain</term>
<term>Lewy Bodies</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Asian Americans</term>
<term>Cohort Studies</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Encéphale</term>
<term>Anatomopathologie</term>
<term>Sénescence</term>
<term>Corps Lewy</term>
<term>Pesticide</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Pesticide</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Although organochlorines have been reported more frequently in Parkinson's disease (PD) brains than in controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during midlife, represent a population well suited to determining the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS. The study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites. With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found in at least 1 brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. The prevalence of Lewy pathology was 75% (6 of 8) among brains with any 2 of the 3 compounds, 48.8% (79 of 162) among those with 1, and 32.7% (18 of 55) for those with neither (P = .007 test for trend). Although findings persisted after removing cases with PD and dementia with Lewy bodies and after adjustment for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (P = .013), the results were insignificant when correcting for multiple testing. Although consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Caroline du Nord</li>
<li>Hawaï</li>
<li>Maryland</li>
<li>Pennsylvanie</li>
<li>Virginie</li>
<li>Virginie-Occidentale</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Hawaï"><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
</region>
<name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name>
<name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D." last="Abbott">Robert D. Abbott</name>
<name sortKey="Duda, John E" sort="Duda, John E" uniqKey="Duda J" first="John E." last="Duda">John E. Duda</name>
<name sortKey="Duda, John E" sort="Duda, John E" uniqKey="Duda J" first="John E." last="Duda">John E. Duda</name>
<name sortKey="Launer, Lenore" sort="Launer, Lenore" uniqKey="Launer L" first="Lenore" last="Launer">Lenore Launer</name>
<name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name>
<name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name>
<name sortKey="Masaki, Kamal" sort="Masaki, Kamal" uniqKey="Masaki K" first="Kamal" last="Masaki">Kamal Masaki</name>
<name sortKey="Miller, Diane B" sort="Miller, Diane B" uniqKey="Miller D" first="Diane B." last="Miller">Diane B. Miller</name>
<name sortKey="Noorigian, Joseph V" sort="Noorigian, Joseph V" uniqKey="Noorigian J" first="Joseph V." last="Noorigian">Joseph V. Noorigian</name>
<name sortKey="O Callaghan, James P" sort="O Callaghan, James P" uniqKey="O Callaghan J" first="James P." last="O'Callaghan">James P. O'Callaghan</name>
<name sortKey="Pellizzari, Edo" sort="Pellizzari, Edo" uniqKey="Pellizzari E" first="Edo" last="Pellizzari">Edo Pellizzari</name>
<name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name>
<name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G. Webster" last="Ross">G. Webster Ross</name>
<name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. Tanner</name>
<name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
<name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R." last="White">Lon R. White</name>
</country>
</tree>
</affiliations>
</record>

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Movement Disorders (revue)

Brain Organochlorines and Lewy Pathology: The Honolulu-Asia Aging Study

Brain Organochlorines and Lewy Pathology: The Honolulu-Asia Aging Study

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	Movement Disorders (revue)
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